Region Guide
Mark Twain Region
A visit to Mark Twain Region is a wonderful opportunity to explore the romantic lore of the mighty Mississippi River, which flows slowly and lazily along the eastern edge of the state.
Charming river towns and friendly villages welcome travelers to the Mark Twain Region, named for the beloved author who made this area his home.
No matter where you start or end your visit, you’re sure to catch the spirit of the magnificent Mississippi River. The Mark Twain Region’s unique blend of tradition, history, excitement and entertainment combine to create an experience you’ll never forget.
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More from Mark Twain Region
Cities
Cities to Explore
Clarksville
Clarksville is located on the Missouri Great River Road, a National Scenic Byway and one…
Explore →Outdoors
Lakes & Parks
Lakes
Parks
No parks listed yet.
Events
Upcoming Events
Mar
14–15
50 Miles of Art Studio Tours
Louisiana
Apr
25
Annual Loafers Car Show
Hannibal
May
9
Annual Car Show & Cruise
Monroe City
May
16
City Wide Garage Sale
Bowling Green
May
16
Mexico Missouri Yard Sales
Mexico
May
16
Chili Cook-Off
Clarksville
May
25
Memorial Day Parade & Service
Memphis
Jul
2
Car Show
Canton
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Explore Mark Twain Region by Category
Golf Courses
- 18 in Mark Twain Region
Festivals
- 18 in Mark Twain Region
Museums
- 13 in Mark Twain Region
Campgrounds
- 11 in Mark Twain Region
Holidays
- 8 in Mark Twain Region
City Wide Garage Sales
- 6 in Mark Twain Region