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On the National Register of Historic Places, the railroad depot allows a historic look at the S.E. Missouri region through historical and cultural exhibits. National and local events change monthly.

Attractions and Upcoming Events

Things to do near Sikeston, MO

National Shrine of Our Lady of the Miraculous Medal

St. Mary's of the Barrens Church (dates to 1827), Marian Grotto and gift shop....

Historical Museum of Mississippi County

Housed in the old City Hall, the museum contains displays, paper and artifacts significant to the community and county....

Twin Bridge Park

RV sites, tent sites, electricity, swimming, fishing, trails, toilets, shower, playground, and ADA accessible....

Perry County Museum

Located in city park, general history museum with military items, early medical equipment, school memorabilia, religious disp...

Marquand Historic Park

Sitzes Homestead Memorial Rose Garden Depot Replication. Tours of homestead by appointment. Regulation horseshoe pits....