The Santa Fe Depot was built in 1906 and is the only remaining depot of Kansas' first railroad south of the Kaw, the Leavenworth, Lawrence, and Ft. Gibson.
It includes unique architectural features of triple arched windows, floor water cooler, dual gas/electric lighting system, coal fireplace, and native limestone belt trim and buff brick veneer.
It welcomed both Presidents William Howard Taft and Theodore Roosevelt when they visited Baldwin in 1911 and 1912. William McKinley also arrived in Baldwin on this railroad for a "whistle stop" during his campaign for the Presidency.
The building is listed on the National Register of Historic Places and now belongs to the Santa Fe Trail Historical Society. It now serves as the departure point for the Midland Railway as well as offering historical displays of the railroad and Baldwin and Santa Fe Trail heritage.