The Osage Mission-Neosho County Museum proudly welcomes visitors to its recently completed museum complex located across the highway from the historic St. Francis Catholic Church. Artifacts and area history dating back to the earliest settlement of the area by the Osage Indians and during the Louisiana Territory acquisition by France and subsequently the founding of the Catholic Osage Mission are included in the Museum building.

The main exhibit area of the museum features a log cabin that was moved from north of Erie. The cabin remained on its original Log Cabin site 5 1/2 miles northwest of Erie from 1876 until it was moved to the museum. The cabin escaped decay for years as the center of a large barn that was built around it sometime in the 1880s.