Seneca plays an important role in our Nation's history. The first home station west of St. Joseph, Missouri (the Eastern starting point of the Pony Express run) was located at Seneca. On the corner of 4th and Main Streets, a monument marks the home station for the Pony Express riders. The famous Smith Hotel once stood where the boulder is placed. The Pony Express riders traveled on the Main Street of Seneca as they passed through town.