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On the National Register of Historic Places, the railroad depot allows a historic look at the S.E. Missouri region through historical and cultural exhibits. National and local events change monthly.

Attractions and Upcoming Events

Things to do near Sikeston, MO

Red House Interpretive Center

The Interpretative Center is a museum focusing on the 1803 time period, the Mississippi River, the life and times of Louis Lo...

Mingo National Wildlife Refuge

Mingo National Wildlife Refuge is 21,676 acres of bottomland hardwood, swamp and wetland. Mingo lies in a linear basin formed...

Missouri Wall of Fame

The Missouri Wall of Fame highlights famous persons from Missouri; other murals can be toured throughout the city....

Southeast Missouri State University Museum

Collections of Mississippian Indian pottery and tools, 1904 World's Fair statuary, fine arts exhibitions, and regional histor...

Marquand Historic Park

Sitzes Homestead Memorial Rose Garden Depot Replication. Tours of homestead by appointment. Regulation horseshoe pits....